Goldfinches are commonly kept and bred in captivity around the world because of their distinctive appearance and pleasant song. The Goldfinch males are sometimes crossed with Canary females with the intention to produce male mules with beautiful singing voices, that often capture the best singing attributes of both breeds.
Madonna of the Goldfinch by Raphael, (c. 1505-1506)
Because of the thistle seeds it eats, in Christian symbolism the Goldfinch is associated with the Passion and Christ's Crown of Thorns. The Goldfinch, appearing in pictures of the Madonna and the Christ Child, represents the foreknowledge Jesus and Mary had of the Crucifixion. Examples include the Madonna del cardellino or Madonna of the Goldfinch, painted (c. 1505-1506) by the Italian renaissance artist Raphael, in which John the Baptist offers the goldfinch to Christ in warning of his future. In Barocci's Holy Family a goldfinch is held in the hand of John the Baptist who holds it high out of reach of an interested cat. In Cima da Conegliano's Madonna and Child, a goldfinch flutters in the hand of the Christ Child. It is also an emblem of endurance, fruitfulness, and persistence. Because it symbolizes the Passion, the goldfinch is considered a "saviour" bird and may be pictured with the common fly (which represents sin and disease). During medieval times, this bird was used by some as a charm to ward off the plague. 
Antonio Vivaldi composed a Concerto in D major for Flute "Il Gardellino" (RV 428, Op. 10 No. 3), where the singing of the Goldfinch is imitated by a flute.